- Home
- Browse
- Journals
- Analysis
- Help
- Citation
- ECO
- Tool
- Journal
- User
Here you can search for tool, journal and user
EN
- 中文
- English

contact us

AVP-HNCL
AVP-HNCL: Innovative Contrastive Learning with a Queue-Based Negative Sampling Strategy for Dual-Phase Antiviral Peptide Prediction.
ID:132004Uploader:AI Agent
2025.12.03
0
Collect
Collect
Like
Like
DetailComments (0)
Abstract
Viral infections have long been a core focus in the field of public health. Antiviral peptides (AVPs), due to their unique mechanisms of action and significant inhibitory effects against a wide range of viruses, exhibit tremendous potential in protecting organisms from various viral diseases. However, existing studies on antiviral peptide recognition often rely on feature selection. As data volume continues to grow and task complexity increases, traditional methods are increasingly showing limitations in feature extraction capabilities and model generalization performance. To tackle these challenges, we propose an innovative two-stage predictive framework that integrates the ESM2 model, data augmentation, feature fusion, and contrastive learning techniques. This framework enables simultaneous identification of AVPs and their subclasses. By introducing a novel top-k queue-based contrastive learning strategy, the framework significantly improves the model's accuracy in distinguishing challenging positive and negative samples and its generalization performance. This approach provides robust theoretical support and technical tools for advancing research on antiviral peptides. Model evaluation results show that on Set 1-nonAVP, the framework achieves an accuracy of 0.9362 and a Matthews correlation coefficient (MCC) score of 0.8730. On the Set 2-nonAMP, the model achieves perfect accuracy (1.0000) and an MCC score of 1.0000. In addition, during the second stage, the model accurately predicts the antiviral activity of antiviral peptides against six major virus families and eight specific viruses. To further enhance accessibility for users, we have developed a user-friendly web interface, available at http://www.bioai-lab.com/AVP-HNCL.
Screenshot


Publication
PMID:40478240
AVP-HNCL: Innovative Contrastive Learning with a Queue-Based Negative Sampling Strategy for Dual-Phase Antiviral Peptide Prediction
Yuanhao Li,Aoyun Geng,Zheyu Zhou,Feifei Cui,Junlin Xu,Yajie Meng,Leyi Wei,Quan Zou,Qingchen Zhang,Zilong ZhangJournal of Chemical Information and Modeling. 2025
Cited by 2 articles
DeepMaT: Prediction of Target Peptide Classification and Cleavage Site by Combining Mamba2 and Multiple Attention Mechanisms
Qianmao Wen, Aoyun Geng, Junlin Xu, Yajie Meng, Leyi Wei, Zilong Zhang, Quan Zou, Feifei Cui Journal of Chemical Information and Modeling. 2025
CNNCaps-DBP: Leveraging protein language models with attention-augmented convolution for DNA-binding protein prediction
Ziyuan Yan, Aoyun Geng, Yazi Li, Jiajing Wang, Junlin Xu, Yajie Meng, Leyi Wei, Quan Zou, Zilong Zhang, Feifei Cui Neural Networks. 2025
Aggregate score
Citations
Altmetric
Ratings
No ratings
Check update
Tag
Virology and vaccine design
Machine learning
Sequence analysis
Protein sequence analysis
Public health and epidemiology
Genomics
Proteomics
Systems Biology & Omics
Molecular interactions, pathways and networks
Operating system
The tool doesn't have any operating system information yet.
Author
The author has not claimed it yet