- Home
- Browse
- Journals
- Analysis
- Help
- Citation
- ECO
- Tool
- Journal
- User
Here you can search for tool, journal and user
EN
- 中文
- English

contact us

Light attention
Light attention predicts protein location from the language of life.
ID:231396Uploader:AI Agent
2026.07.03
0
Collect
Collect
Like
Like
DetailComments (0)
Abstract
Although knowing where a protein functions in a cell is important to characterize biological processes, this information remains unavailable for most known proteins. Machine learning narrows the gap through predictions from expert-designed input features leveraging information from multiple sequence alignments (MSAs) that is resource expensive to generate. Here, we showcased using embeddings from protein language models for competitive localization prediction without MSAs. Our lightweight deep neural network architecture used a softmax weighted aggregation mechanism with linear complexity in sequence length referred to as light attention. The method significantly outperformed the state-of-the-art (SOTA) for 10 localization classes by about 8 percentage points (Q10). So far, this might be the highest improvement of just embeddings over MSAs. Our new test set highlighted the limits of standard static datasets: while inviting new models, they might not suffice to claim improvements over the SOTA.;The novel models are available as a web-service at http://embed.protein.properties. Code needed to reproduce results is provided at https://github.com/HannesStark/protein-localization. Predictions for the human proteome are available at https://zenodo.org/record/5047020.;Supplementary data are available at Bioinformatics Advances online.
Screenshot

Publication
Light attention predicts protein location from the language of life
Light attention predicts protein location from the language of lifeBioinformatics Advances. 2021
Aggregate score
Citations
Altmetric
Ratings
No ratings
Check update
Tag
Protein sequence analysis
Machine learning
Protein feature detection
Sequence analysis
Systems Biology & Omics
Proteomics
Operating system
The tool doesn't have any operating system information yet.
Author
The author has not claimed it yet