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XPN
Merging two gene-expression studies via cross-platform normalization
ID:37285Uploader:BioTreasury
2022.01.19
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Abstract
Motivation: Gene-expression microarrays are currently being applied in a variety of biomedical applications. This article considers the problem of how to merge datasets arising from different gene-expression studies of a common organism and phenotype. Of particular interest is how to merge data from different technological platforms. Results: The article makes two contributions to the problem. The first is a simple cross-study normalization method, which is based on linked gene/sample clustering of the given datasets. The second is the introduction and description of several general validation measures that can be used to assess and compare cross-study normalization methods. The proposed normalization method is applied to three existing breast cancer datasets, and is compared to several competing normalization methods using the proposed validation measures. Availability: The supplementary materials and XPN Matlab code are publicly available at website: https://genome.unc.edu/xpn
Publication
Merging two gene-expression studies via cross-platform normalization
Andrey A. Shabalin,Håkon Tjelmeland,Cheng Fan,Charles M. Perou,Andrew B. NobelBioinformatics. 2008
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Tag
Sequencing
Gene expression profiling
Gene expression
Genes & Genomes
Operating system
LINUX
LINUX
WINDOWS
WINDOWS
MAC
MAC
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